The below information is posted because of the recent thread by (tonyjeffs) dealing with the drug scopolamine, and this drugs ability to decrease the flow of the neurotransmitter acetycholine, which caused several patients to report a dramatic reduction in their tinnitus.

The myofascial syndrome causes one classification of tinnitus defined as "roaring tinnitus", characterized by most myofascial patients as hearing the same noise as a seashell held over the ears. In many cases of myofascial, the patient can produce both subjective and objective tinnitus simultaneously. The myofascial syndrome centers itself around striated skeletal muscle fiber bands that are locked into permanent contraction and are able to sustain this contraction indefinitely. Even more distressing from a patients perspective, is the subsequent myofascial trigger point, (contraction knot), that will form inside a taut muscle band. Many prominent physiologists believe this relationship between myofascial and tinnitus is characterized by a perpetual and excessive increase in the flow of acetylcholine across the neuromuscular junction of a striated skeletal muscle. The critical TrP abnormality now appears to be a neuromuscular dysfunction at the motor endplate of an extrafusal skeletal muscle fiber, in which case the myofascial mechanism is a neuromuscular disease.

By using both surface and needle electromyography, and computers with audio channels, physiologists were able to determine TrPs contain electrical active loci that produce characteristic electrical activity, termed as spontaneous electrical activity (SEA). The physiologists have isolated two different sounds in examining TrPs worth mentioning here.
One: A continuous low-amplitude noise-like component, which has a characteristic sound of a seashell, held over the ear.

Two: The second sound was a high-amplitude intermittent component identified as endplate spikes. Physiologist were able to convert this higher, but normal discrete pattern to an abnormal noise-like pattern by applying mild mechanical stress to the terminal nerve fiber or to the endplate region.

Other physiologists have demonstrated experimental production of the same endplate noise-like electrical activity. The "acetycholine-noise", which looks like (SEA) mentioned above, was the result of a 100- to 1000-fold increase in the rate of release of acetycholine across the neuromuscular junction. This abnormal release was induced by the addition of lanthanum ions or by exposing the extrafusal endplate to foreign serum. The patterns correspond closely to the SEA of active loci and the endplate noise of a TrP the physiologist mentioned above. This experiment demonstrates to me, myofascial is not the only source of tinnitus.

Several different physiologists describe this array of sounds as acetylcholine noise, or endplate noise.

I have some questions, and am hoping some of our more knowledgeable board members can help with.

Question 1. Could this continuous low-amplitude noise-like component, which has a characteristic sound of a seashell, held over the ear be subjective tinnitus?

Question 2. This forum had a thread about 10 days ago concerning the following subject matter: Contracting muscle of mastication causes a second component tinnitus sound, heard only while these muscles were actually contracted. Could this temporary tinnitus be linked to the noise described in issue #two above, and could this temporary tinnitus be classified as objective?

Question 3. My thoughts concerning the experimental production of the acetylcholine-noise by increasing the rate of (ACh) across the neuromuscular junction, or exposing the extrafusal endplate to foreign serum: This very much sounds like dose dependent drug-induced tinnitus. Could the resulting acetylcholine-noise be what patients with drug-induced tinnitus are hearing?

Question 4. Could this acetylcholine noise be the actual instigating source of all classifications of tinnitus?

The drug scopolamines ability to reduce the amount a (ACh), and cause a reduction in the volume of tinnitus is too coincidental to let slide.

I purchased a scopolamine patch on Monday, and will leave it on until Thursday. We have to have a physicians prescription to purchase the patch in America; cost is 18.00 + 60.00 for office visit. Is this true everywhere?

John